RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Meccanismi cellulari e molecolari di morte e protezione neuronale
• 2 - Meccanismi molecolari delle neurotrofine e dei loro precursori nella plasticità sinaptica e nella neurodegenerazione
• 3 - Determinanti genetici e molecolari del ruolo della COX-2 nell'aterotrombosi.
• 4 - Meccanismi molecolari del traffico di membrane in neuroni GABAergici e glutamatergici
• 5 - Il sistema endocannabinoide come potenziale modulatore della neurodegenerazione in un modello animale di morbo di Alzheimer.
• 6 - Regolazione della maturazione proteolitica del precursore del peptide beta-amiloide dell'Alzheimer
• 7 - Meccanismi biologici e molecolari nella malattia di Alzheimer
• 8 - APPRENDIMENTO E MEMORIA: STUDIO NEUROFISIOLOGICO E MOLECOLARE
• 9 - NGF e molecole correlate in modelli animali: effetti biologici sulle cellule nervose
• 10 - Livelli tissutali vescicali di Nerve Growth Factor (NGF) in pazienti con iperattività detrusoriale prima e dopo terapia e relazione con la produzione di mediatori di natura lipidica.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • FISIOLOGIA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
    • PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
    • SUGARS; DERIVATIVES THEREOF (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C121/36; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; sugar and starch industry C13)
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Toscana

Bibliografia

1. Bianchi A.L., M. Denavit-Saubié, J. Champagnat. Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters. Physiol. Rev. 75, 1-45, 1995.
2. Bolser D.C., J.A. Hey, R.W. Chapman. Influence of central antitussive drugs on the cough motor pattern. J. Appl. Physiol. 86, 1017-1024, 1999.
3. Bolser, D.C. and P.W. Davenport. Functional organization of the central cough generation mechanism. Pulm.Pharmacol.Ther. 15, 221-225, 2002.
4. Bongianni F., G. Fontana, T. Pantaleo. Effects of electrical and chemical stimulation of the Bötzinger complex on respiratory activity in the cat. Brain Res. 445, 254-261, 1988.
5. Bongianni F., M. Corda, G. Fontana, T. Pantaleo. Expiration-related neurons in the caudal ventral respiratory group of the cat: influences of the activation of Bötzinger complex neurons. Brain Res. 526, 299-302, 1990.
6. Bongianni F., D. Mutolo, T. Pantaleo. Depressant effects on inspiratory and expiratory activity produced by chemical activation of Bötzinger complex neurons in the rabbit. Brain Res. 749, 1-9, 1997.
7. Bongianni F., D. Mutolo, G.A. Fontana, T. Pantaleo. Discharge patterns of Bötzinger complex neurons during cough in the cat. Am. J. Physiol. 274 (Regulatory Integrative Comp. Physiol. 43), R1015-R1024, 1998.
8. Bongianni F., T.G. Deliagina, S. Grillner. Role of glutamate receptors subtypes in the lamprey respiratory network. Brain Res. 826, 298-302, 1999.
9. Bongianni F., D. Mutolo, M. Carfì, T. Pantaleo. Respiratory responses to ionotropic glutamate receptor antagonists in the ventral respiratory group of the rabbit. Plügers Arch. 444 (5), 602-609, 2002.
10. Bongianni F., D. Mutolo, M. Carfì, T. Pantaleo. Group I and II metabotropic glutamate receptors modulate respiratory activity in the lamprey. Eur. J. Neurosci. 16 (3), 454-460, 2002.
11. Brockhaus J. and K. Ballanyi. Synaptic inhibition in the isolated respiratory network of neonatal rats. Eur. J. Neurosci. 10, 3823-3839, 1998.
12. Büsselberg D., A.M. Bischoff, J.F.R. Paton, D.W. Richter. Reorganisation of respiratory network activity after loss of glycinergic inhibition. Plügers Arch. 441, 444-449, 2001.
13. Chitravanshi V.C. and H.N. Sapru. Microinjections of glycine into the pre-Bötzinger complex inhibit phrenic nerve activity in the rat. Brain Res. 947, 25-33, 2002.
14. Del Negro, C.A., C. Morgado-Valle, J.L. Feldman. Respiratory rhythm: an emergent network property? Neuron 34, 821-830, 2002.
15. Dutschmann M. and J.F.R. Paton. Trigeminal reflex regulation of the glottis depends on central glycinergic inhibition in the rat. Am. J. Physiol. 282, R999-R1005, 2002.
16. Ezure K., I. Tanaka, M. Miyazaki. Electrophysiological and pharmacological analysis of synaptic inputs to pulmonary rapidly adapting receptor relay neurons in the rat. Exp. Brain Res., 128, 471-480, 1999.
17. Gray, P.A., W.A. Janczewski, N. Mellen, D.R. McCrimmon, J.L. Feldman. Normal breathing requires preBötzinger complex neurokinin-1 receptor-expressing neurons. Nat.Neurosci. 4, 927-930, 2001.
18. Haji A., R. Takeda, M. Okazaki. Neuropharmacology of control of respiratory rhythm and pattern in mature mammals. Pharmacology & Therapeutics 86, 277-304, 2000.
19. Janczewski, W.A., H. Onimaru, I. Homma, J.L. Feldman. Opioid-resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat. J.Physiol 545, 1017-1026, 2002.
20. Jordan, D. Central nervous pathways and control of the airways. Respir. Physiol, 125, 67-81, 2001.
21. Mazzone, S.B. and B.J. Canning. Central nervous system control of the airways: pharmacological implications. Current Opinion in Pharmacology, 2, 220-228, 2002.
22. Mellen, N.M., W.A. Janczewski, C.M. Bocchiaro, J.L. Feldman. Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation. Neuron 37, 821-826, 2003.
23. Mutolo D., F. Bongianni, M. Carfì, T. Pantaleo. Respiratory changes induced by kainic acid lesions in rostral ventral respiratory group of rabbits. Amer. J. Physiol. 283, R227-242, 2002.
24. Mutolo D., F. Bongianni, T. Pantaleo. Effects of lignocaine blockades and kainic acid lesions in the Bötzinger complex on the spontaneous expiratory activity and cough reflex responses in the rabbit. Neurosci. Letters 332, 175-179, 2002.
25. Mutolo D., F. Bongianni, T. Pantaleo. Respiratory role of ionotropic glutamate receptors in the rostral ventral respiratory group of the rabbit. In: Advance in experimental medicine and biology. Kluwer Academic/Plenum Publisher, New York, 2004 (in press).
26. Oku, Y., I. Tanaka, K. Ezure. Activity of bulbar respiratory neurons during fictive coughing and swallowing in the decerebrate cat. J.Physiol 480, 309-324, 1994.
27. Onimaru H., A. Arata, I. Homma. Inhibitory synaptic inputs to the respiratory rhythm generator in the medulla isolated from newbornrats. Pflügers Arch. 417, 425-432, 1990.
28. Onimaru, H. and I. Homma. A novel functional neuron group for respiratory rhythm generation in the ventral medulla. J.Neurosci. 23, 1478-1486, 2003.
29. Pantaleo T., F. Bongianni, D. Mutolo. Central nervous mechanisms of cough. Pulm. Pharmacol. Ther. 15, 227-233, 2002.
30. Pierrefiche O., S.W. Schwarzacher, A.M. Bischoff, D.W. Richter. Blockade of synaptic inhibition within the pre-Bötzinger complex in the cat suppresses respiratory rhythm generation in vivo. J. Physiol. 509, 245-254, 1998.
31. Rekling J.C. and J.L. Feldman. PreBötzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation. Annu. Rev. Physiol. 60, 385-405, 1998.
32. Rovainen, C.M. Neural control of ventilation in the lamprey. Fed. Proc., 36, 2386-2389, 1977.
33. Rovainen, C.M. Generation of respiratory activity by the lamprey brain exposed to picrotoxin and strychnine, and weak synaptic inhibition in motoneurons. Neuroscience 10, 875-882, 1983.
34. Russell, D.F. Respiratory pattern generation in adult lampreys (Lampetra fluviatilis): interneurons and burst resetting. J. Comp. Physiol.[A], 158, 91-102, 1986.
35. Rybak, I.A., N.A. Shevtsova, W.M. St John, J.F. Paton, O. Pierrefiche. Endogenous rhythm generation in the pre-Botzinger complex and ionic currents: modelling and in vitro studies. Eur.J.Neurosci. 18, 239-257, 2003.
36. Shannon, R., D.M. Baekey, K.F. Morris, B.G. Lindsey. Ventrolateral medullary respiratory network and a model of cough motor pattern generation. J.Appl.Physiol 84, 2020-2035, 1998.
37. Shannon, R., D.M. Baekey, K.F. Morris, Z. Li, B.G. Lindsey. Functional connectivity among ventrolateral medullary respiratory neurones and responses during fictive cough in the cat. J.Physiol 525, 207-224, 2000.
38. Smith J.C., R.J. Butera, N. Koshiya, C. Del Negro, C.G. Wilson, S.M. Johnson. Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker-network model. Resp. Physiol. 122, 131-147, 2000.
39. St-Jacques R. and W.M. St-John. Transient, reversible apnoea following ablation of the pre-Bötzinger complex in rats. J. Physiol. 520 , 303-314, 1999.
40. Takeda, S., L.I. Eriksson, Y. Yamamoto, H. Joensen, H. Onimaru, S.G. Lindahl. Opioid action on respiratory neuron activity of the isolated respiratory network in newborn rats. Anesthesiology 95, 740-749, 2001.
41. Thompson, K.J. Organization of inputs to motoneurons during fictive respiration in the isolated lamprey brain. J. Comp. Physiol. [A], 157, 291-302, 1985.
42. Wassermann A.M., M. Ferreira, N. Sahibzada, Y.M. Hernandez, R. Gillis. GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat. Am. J. Physiol. 283, R1423-R1441, 2002.
43. Widdicombe, J.G. Neurophysiology of the cough reflex. Eur.Respir.J. 8, 1193-1202, 1995.
44. Zhang W., F. Elsen, A. Barnrok, D.W. Richter. Postnatal development of GABAB receptor-mediated modulation of voltage-activated Ca2+ currents in mouse brainstem neurones. Eur. J. Neurosci. 11, 2332-2342, 1999.

Parole Chiave

CONTROLLO DELLA RESPIRAZIONE; GRUPPO RESPIRATORIO VENTRALE; TOSSE; NUCLEO DEL TRATTO SOLITARIO; AMINOACIDI ECCITATORI; AMINOACIDI INIBITORI; NUCLEO COMMISSURALE; OPPIOIDI